N-1 substituted pyrimidin-4-ones: novel, orally active inhibitors of lipoprotein-associated phospholipase A2-Reference-Cited by-同舟云学术

N-1 substituted pyrimidin-4-ones: novel, orally active inhibitors of lipoprotein-associated phospholipase A2

Published:2000-11 Issue:22 Volume:10 Page:2557-2561
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Boyd Helen F.,Fell Stephen C.M.,Flynn Sean T.,Hickey Deirdre M.B.,Ife Robert J.,Leach Colin A.,Macphee Colin H.,Milliner Kevin J.,Moores Kitty E.,Pinto Ivan L.,Porter Rod A.,Rawlings D.Anthony,Smith Stephen A.,Stansfield Ian G.,Tew David G.,Theobald Colin J.,Whittaker Caroline M.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference11 articles.

1. Mechanism of Inhibition of LDL Phospholipase A2 by Monocyclic-β-lactams. Burst Kinetics and the Effect of Stereochemistry

2. The enzyme is also known as PAF acetyl hydrolase, though it is clear that the enzyme has much broader substrate specificity than this name implies. See Tew, D. G.; Southan, C.; Rice, S. Q. J.; Lawrence, M. P.; Haodong, L.; Boyd, H. F.; Moores, K.; Gloger, I. S.; Macphee, C. H. Atheroscler. Thromb. Vasc. Biol. 1996, 16(4), 591.

3. 2-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A 2

4. See Agathocleous, D. C.; Shaw, G. J. J. Chem. Soc., Perkin Trans. 1 1993, 2555.

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