Bioactive hydroxyethylene dipeptide isosteres with hydrophobic (P3-P1)-moieties. A novel strategy towards small non-peptide renin inhibitors-Reference-Cited by-同舟云学术

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Bioactive hydroxyethylene dipeptide isosteres with hydrophobic (P3-P1)-moieties. A novel strategy towards small non-peptide renin inhibitors

Published:1996-07 Issue:13 Volume:6 Page:1589-1594
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Rasetti Vittorio,Cohen N.Claude,Rüeger Heinrich,Göschke Richard,Maibaum Jürgen,Cumin Frederic,Fuhrer Walter,Wood Jeanette M.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference38 articles.

1. Hypertension: Pathophysiology, Diagnosis and Management;Sealey,1995

2. Hypertension: Pathophysiology, Diagnosis and Management;Waeber,1995

3. Renin inhibitors

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1. Applications of amide isosteres in medicinal chemistry;Bioorganic & Medicinal Chemistry Letters;2019-09

2. Renin Inhibitor for the Treatment of Hypertension: Design and Discovery of Aliskiren;Structure-Based Design of Drugs and Other Bioactive Molecules;2015-05-29

3. Discovery of Peptide Drugs as Enzyme Inhibitors and Activators;Peptide Chemistry and Drug Design;2015-02-13

4. Tailoring Peptidomimetics for Targeting Protein–Protein Interactions;Molecular Cancer Research;2014-03-18

5. Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors;Bioorganic & Medicinal Chemistry Letters;2012-07

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