Pyrimido[1,2- b ]-1,2,4,5-tetrazin-6-ones as HCMV protease inhibitors: a new class of heterocycles with flavin-like redox properties

Author:

Di Grandi Martin J.,Curran Kevin J.,Baum Ellen Z.,Bebernitz Geraldine,Ellestad George A.,Ding Wei-Dong,Lang Stanley A.,Rossi Miriam,Bloom Jonathan D.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference17 articles.

1. Mocarski, E. S. In Virology; Fields, B. N., Knipe, D. M., Howley, P. M., Eds; Lippincott-Raven: Philadelphia, PA, 1996; p 2447. Britt, W. J.; Alford, C. A. In Virology; Fields, B. N., Knipe, D. M., Howley, P. M., Eds, Lippincott-Raven: Philadelphia, PA, 1996; p 2493.

2. A Controlled Trial of Valganciclovir as Induction Therapy for Cytomegalovirus Retinitis

3. Identification and Characterization of a Herpes Simplex Virus Gene Product Required for Encapsidation of Virus DNA

4. The protease of herpes simplex virus type 1 is essential for functional capsid formation and viral growth

5. Non-Nucleoside Inhibitors of the Human Cytomegalovirus

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