A six-weekly dosing schedule for pembrolizumab in patients with cancer based on evaluation using modelling and simulation

Author:

Lala Mallika,Li Tommy RuosiORCID,de Alwis Dinesh P.,Sinha Vikram,Mayawala Kapil,Yamamoto Noboru,Siu Lillian L.,Chartash Elliot,Aboshady Hesham,Jain Lokesh

Funder

IV

Merck Sharp & Dohme Corp.

Merck & Co., Inc.

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference19 articles.

1. Keytruda [package insert],2017

2. Pembrolizumab for the treatment of non-small-cell lung cancer;Garon;N Engl J Med,2015

3. Pembrolizumab: role of modeling and simulation in bringing a novel immunotherapy to patients with melanoma;de Greef;CPT Pharmacometrics Syst Pharmacol,2017

4. Evaluation of dosing strategy for pembrolizumab for oncology indications;Freshwater;J Immunother Cancer,2017

5. Providing clinical evidence of effectiveness for human drug and biological products,1998

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