Osimertinib versus osimertinib plus chemotherapy for non–small cell lung cancer with EGFR (T790M)-associated resistance to initial EGFR inhibitor treatment: An open-label, randomised phase 2 clinical trial

Author:

Tanaka Kentaro,Asahina HajimeORCID,Kishimoto Junji,Miyata Yoshihiro,Uchida Takahiro,Watanabe Kana,Hamai KosukeORCID,Harada Taishi,Tsubata YukariORCID,Sugawara ShunichiORCID,Kobayashi Kunihiko,Sugio Kenji,Oizumi Satoshi,Okamoto Isamu

Funder

AstraZeneca

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference19 articles.

1. AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer;Cross;Canc Discov,2014

2. AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer;Janne;N Engl J Med,2015

3. Osimertinib or platinum-pemetrexed in EGFR t790m-positive lung cancer;Mok;N Engl J Med,2017

4. Mechanisms of osimertinib resistance and emerging treatment options;Schmid;Lung Canc,2020

5. Emerging treatment paradigms for EGFR-mutant lung cancers progressing on osimertinib: a review;Piper-Vallillo;J Clin Oncol,2020

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