The Ex Vivo Treatment of Donor T Cells with Cosalane, an HIV Therapeutic and Small-Molecule Antagonist of CC-Chemokine Receptor 7, Separates Acute Graft-versus-Host Disease from Graft-versus-Leukemia Responses in Murine Hematopoietic Stem Cell Transplantation Models-Reference-Cited by-同舟云学术

The Ex Vivo Treatment of Donor T Cells with Cosalane, an HIV Therapeutic and Small-Molecule Antagonist of CC-Chemokine Receptor 7, Separates Acute Graft-versus-Host Disease from Graft-versus-Leukemia Responses in Murine Hematopoietic Stem Cell Transplantation Models

Published:2019-06 Issue:6 Volume:25 Page:1062-1074
ISSN:1083-8791
Container-title:Biology of Blood and Marrow Transplantation
language:en
Short-container-title:Biology of Blood and Marrow Transplantation

Author:

Fowler Kenneth A.,Li Kelin,Whitehurst Christopher B.,Bruce Danny W.,Moorman Nathaniel J.,Aubé Jeffrey,Coghill James M.^ORCID

Publisher

Elsevier BV

Subject

Transplantation,Hematology

Reference20 articles.

1. Separation of graft-versus-host disease from graft-versus-leukemia responses by targeting CC-chemokine receptor 7 on donor T cells;Coghill;Blood,2010

2. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs;Förster;Cell,1999

3. A high migratory capacity of donor T-cells in response to the lymph node homing receptor CCR7 increases the incidence and severity of GvHD;Portero-Sainz;Bone Marrow Transplant,2017

4. A high proportion of CD4+ T cells expressing the lymph-node homing chemokine receptor CCR7 increases incidence and severity of acute graft-versus-host disease in patients undergoing allogeneic transplantation for hematological malignancy;Yakoub-Agha;Leukemia,2006

5. Identification of cosalane as an inhibitor of human and murine CC-chemokine receptor 7 signaling via a high-throughput screen;Hull-Ryde;SLAS Discov,2018

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