Thermostable designed ankyrin repeat proteins (DARPins) as building blocks for innovative drugs

Author:

Schilling JohannesORCID,Jost ChristianORCID,Ilie Ioana MariucaORCID,Schnabl JoachimORCID,Buechi Oralea,Eapen Rohan S.ORCID,Truffer Rafaela,Caflisch AmedeoORCID,Forrer PatrikORCID

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference46 articles.

1. A novel strategy to design binding molecules harnessing the modular nature of repeat proteins;Forrer;FEBS Lett.,2003

2. Designing repeat proteins: Well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins;Binz;J. Mol. Biol.,2003

3. High-affinity binders selected from designed ankyrin repeat protein libraries;Binz;Nat. Biotechnol.,2004

4. Protein scaffolds, design, synthesis, and applications;Boersma;Methods Mol. Biol.,2018

5. Profound functional suppression of tumor-infiltrating T-cells in ovarian cancer patients can be reversed using PD-1-blocking antibodies or DARPin proteins;Foord;J. Immunol. Res.,2020

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