A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2-Reference-Cited by-同舟云学术

A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2

Published:2022-08 Issue:8 Volume:298 Page:102228
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Scoles Daniel R.,Gandelman Mandi,Paul Sharan,Dexheimer Thomas,Dansithong Warunee,Figueroa Karla P.,Pflieger Lance T.,Redlin Scott,Kales Stephen C.,Sun Hongmao,Maloney David,Damoiseaux Robert,Henderson Mark J.,Simeonov Anton,Jadhav Ajit,Pulst Stefan M.

Funder

National Institutes of Health

National Institute of Neurological Disorders and Stroke

National Center for Advancing Translational Sciences

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference48 articles.

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3. Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2;Pulst;Nat. Genet.,1996

4. Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS;Elden;Nature,2010

5. Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice;Becker;Nature,2017

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