TDP43 and huntingtin Exon-1 undergo a conformationally specific interaction that strongly alters the fibril formation of both proteins-Reference-Cited by-同舟云学术

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TDP43 and huntingtin Exon-1 undergo a conformationally specific interaction that strongly alters the fibril formation of both proteins

Published:2024-09 Issue:9 Volume:300 Page:107660
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

George Gincy,Ajayan Anakha,Varkey Jobin,Pandey Nitin K.^ORCID,Chen Jeannie,Langen Ralf

Funder

NIH

Publisher

Elsevier BV

Reference82 articles.

1. Huntington's disease;Walker;The Lancet,2007

2. CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion;Lee;Neurology,2012

3. CAG repeat number governs the development rate of pathology in Huntington's disease;Penney;Ann. Neurol. Official J. Am. Neurol. Assoc. Child Neurol. Soc.,1997

4. A worldwide study of the Huntington's disease mutation: the sensitivity and specificity of measuring CAG repeats;Kremer;New Engl. J. Med.,1994

5. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice;Mangiarini;Cell,1996

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