A phase transition reduces the threshold for nicotinamide mononucleotide-based activation of SARM1, an NAD(P) hydrolase, to physiologically relevant levels
Author:
Funder
NIAMDD
NINDS
National Institutes of Health
NIGMS
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference46 articles.
1. Programmed axon degeneration: from mouse to mechanism to medicine;Coleman;Nat. Rev. Neurosci.,2020
2. The SARM1 Toll/interleukin-1 receptor domain possesses intrinsic NAD(+) cleavage activity that promotes pathological axonal degeneration;Essuman;Neuron,2017
3. TIR domain proteins are an Ancient Family of NAD(+)-Consuming enzymes;Essuman;Curr. Biol.,2018
4. SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites;Angeletti;iScience,2022
5. A cell-permeant mimetic of NMN activates SARM1 to produce cyclic ADP-ribose and induce non-apoptotic cell death;Zhao;iScience,2019
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