The disordered regions of the methyltransferase SETD2 govern its function by regulating its proteolysis and phase separation
Author:
Funder
National Institute of General Medical Sciences
Stowers Institute for Medical Research
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference81 articles.
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2. The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation;Dhayalan;J. Biol. Chem.,2010
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1. Phase Separation of Chromatin Structure-related Biomolecules: A Driving Force for Epigenetic Regulations;Current Protein & Peptide Science;2024-09
2. Catalytic activity of Setd2 is essential for embryonic development in mice: establishment of a mouse model harboring patient-derived Setd2 mutation;Frontiers of Medicine;2024-08-08
3. Set2 regulates Ccp1 and Swc2 to ensure centromeric stability by retargeting CENP-A;Nucleic Acids Research;2024-03-05
4. Protein phase separation disorder as a potentially pervasive pathogenic mechanism of male infertility;Medical Hypotheses;2023-12
5. SETD2 maintains nuclear lamina stability to safeguard the genome;2023-09-29
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