Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides
Author:
Funder
National Institutes of Health
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference35 articles.
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3. Deciphering Alzheimer disease;Selkoe;Cold Spring Harb Perspect. Med.,2012
4. The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase;Bolduc;Elife,2016
5. Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase;Takagi-Niidome;J. Neurosci.,2015
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