Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages-Reference-Cited by-同舟云学术

Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages

Published:2022-02 Issue:2 Volume:298 Page:101501
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Williams Niamh C.,Ryan Dylan G.,Costa Ana S.H.^ORCID,Mills Evanna L.^ORCID,Jedrychowski Mark P.,Cloonan Suzanne M.^ORCID,Frezza Christian,O'Neill Luke A.

Funder

European Research Council

Science Foundation Ireland

Wellcome Trust

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference34 articles.

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2. Metabolic reprograming in macrophage polarization;Galván-Peña;Front. Immunol.,2014

3. Coupling Krebs cycle metabolites to signalling in immunity and cancer;Ryan;Nat. Metab.,2019

4. Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages;Mills;Cell,2016

5. Succinate is an inflammatory signal that induces IL-1β through HIF-1α;Tannahill;Nature,2013

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