Von Hippel–Lindau (VHL) small-molecule inhibitor binding increases stability and intracellular levels of VHL protein
Author:
Funder
National Council for Eurasian and East European Research
Cancer Research UK
Wellcome Trust
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference51 articles.
1. Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase;Kamura;Science,1999
2. Crystal structure of the Cul2-Rbx1-EloBC-VHL ubiquitin ligase complex;Cardote;Structure,2017
3. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation;Jaakkola;Science,2001
4. A review of von Hippel-Lindau syndrome;Varshney;J. Kidney Cancer VHL,2017
5. Sequential pathogenesis of metastatic VHL mutant clear cell renal cell carcinoma: Putting it together with a translational perspective;Shenoy;Ann. Oncol.,2016
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