Randomized controlled trials of switching to a new medication vs continuing a chronic medication may underestimate the risk of adverse events in those continuing because of asymmetric depletion of susceptibles

Author:

Colacci Michael,Raissi Afsaneh,Ray Prachi,Sholzberg Michelle,Rothman Kenneth J.,Fralick Michael

Publisher

Elsevier BV

Reference14 articles.

1. Apixaban versus warfarin in patients with atrial fibrillation;Granger;N Engl J Med,2011

2. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation;Patel;N Engl J Med,2011

3. Direct oral anticoagulants versus warfarin in patients with atrial fibrillation: patient-level network meta-analyses of randomized clinical trials with interaction testing by age and sex;Carnicelli;Circulation,2022

4. Safety of switching from a vitamin K antagonist to a non-vitamin K antagonist oral anticoagulant in frail older patients with atrial fibrillation: results of the FRAIL-AF randomized controlled trial;Joosten;Circulation,2023

5. FRAIL-AF: warfarin beats NOACs in frail elderly with AF,2023

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