Trastuzumab-Emtansine and Osimertinib Combination Therapy to Target HER2 Bypass Track Resistance in EGFR Mutation-Positive NSCLC
Author:
Funder
F. Hoffmann-La Roche Ltd
Roche Nederland
AstraZeneca
Publisher
Elsevier BV
Subject
Pulmonary and Respiratory Medicine,Oncology
Reference12 articles.
1. Trastuzumab emtansine delays and overcomes resistance to the third-generation EGFR-TKI osimertinib in NSCLC EGFR mutated cell lines;La Monica;J Exp Clin Cancer Res,2017
2. Trastuzumab and paclitaxel in patients with EGFR mutated NSCLC that express HER2 after progression on EGFR TKI treatment;de Langen;Br J Cancer,2018
3. LBA50 - Mechanisms of acquired resistance to first-line osimertinib: preliminary data from the phase III FLAURA study;Ramalingam;Ann Oncol,2018
4. Trastuzumab emtansine is active on HER-2 overexpressing NSCLC cell lines and overcomes gefitinib resistance;Cretella;Mol Cancer,2014
5. Gefitinib plus chemotherapy versus placebo plus chemotherapy in EGFR-mutation-positive non-small-cell lung cancer after progression on first-line gefitinib (IMPRESS): a phase 3 randomised trial;Soria;Lancet Oncol,2015
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