The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K+ channels TREK-1 and TRAAK-Reference-Cited by-同舟云学术

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The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K+ channels TREK-1 and TRAAK

Published:2001-02 Issue:1 Volume:892 Page:94-101
ISSN:0006-8993
Container-title:Brain Research
language:en
Short-container-title:Brain Research

Author:

Meadows H.J.,Chapman C.G.,Duckworth D.M.,Kelsell R.E.,Murdock P.R.,Nasir S.,Rennie G.,Randall A.D.

Publisher

Elsevier BV

Subject

Developmental Biology,Clinical Neurology,Molecular Biology,General Neuroscience

Reference18 articles.

1. TASK, a human background K+ channel to sense external pH variations near physiological pH;Duprat;EMBO J.,1997

2. The neuroprotective agent riluzole activates the two P domain K+ channels TREK-1 and TRAAK;Duprat;Mol. Pharmacol.,2000

3. A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids;Fink;EMBO J.,1998

4. Mechanisms of ischaemic damage to central white matter axons: a quantitative histological analysis using rat optic nerve;Garthwaite;Neuroscience,1999

5. Sipatrigine (BW 619C89) is a neuroprotective agent and a sodium and calcium channel inhibitor;Hainsworth;CNS Drug Rev.,2000

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1. TREK channels in Mechanotransduction: a Focus on the Cardiovascular System;Frontiers in Cardiovascular Medicine;2023-05-23

2. The Two-Pore Domain Potassium Channel TREK-1 Promotes Blood–Brain Barrier Breakdown and Exacerbates Neuronal Death After Focal Cerebral Ischemia in Mice;Molecular Neurobiology;2022-01-24

3. Two-Pore-Domain Potassium (K2P-) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes;Cells;2021-10-27

4. Are TREK Channels Temperature Sensors?;Frontiers in Cellular Neuroscience;2021-10-06

5. Block of TREK and TRESK K2P channels by lamotrigine and two derivatives sipatrigine and CEN-092;Biochemistry and Biophysics Reports;2021-07

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