Mosunetuzumab Safety Profile in Patients With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma: Clinical Management Experience From a Pivotal Phase I/II Trial

Author:

Matasar MatthewORCID,Bartlett Nancy L.,Shadman Mazyar,Budde Lihua E.,Flinn Ian,Gregory Gareth P.,Kim Won Seog,Hess Georg,El-Sharkawi DimaORCID,Diefenbach Catherine S.,Huang Huang,To Iris,Parreira JoanaORCID,Wu Mei,Kwan Antonia,Assouline Sarit

Funder

F. Hoffmann-La Roche Ltd

F. Hoffmann-La Roche

Genentech

Publisher

Elsevier BV

Subject

Cancer Research,Oncology,Hematology

Reference22 articles.

1. Anti-CD20/CD3 T cell-dependent bispecific antibody for the treatment of B cell malignancies;Sun;Sci Transl Med,2015

2. Pharmacodynamic effects and immune correlates of response to the CD20/CD3 bispecific antibody mosunetuzumab in relapsed or refractory non-Hodgkin lymphoma;Hernandez;Blood,2019

3. Single-agent mosunetuzumab shows durable complete responses in patients with relapsed or refractory B-cell lymphomas: phase I dose-escalation study;Budde;J Clin Oncol,2021

4. Safety and efficacy of mosunetuzumab, a bispecific antibody, in patients with relapsed or refractory follicular lymphoma: a single-arm, multicentre, phase 2 study;Budde;Lancet Oncol,2022

5. Roche Pharma AG. Summary of product characteristics: Lunsumio 1 mg concentrate for solution for infusion and Lunsumio 30 mg concentrate for solution for infusion. 2023. Available from: https://www.ema.europa.eu/en/documents/product-information/lunsumio-epar-product-information_en.pdf accessed November 29, 2023.

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