Safety and immunogenicity of live attenuated human–bovine (UK) reassortant rotavirus vaccines with VP7-specificity for serotypes 1, 2, 3 or 4 in adults, children and infants1This study was presented, in part, in a poster session at the Fifth Rotavirus Vaccine Workshop held on October 16–17, 1995, at the Centers for Disease Control and Prevention in Atlanta, GA. Informed consent was obtained from adult volunteers and the parents or guardians of pediatric participants. The guidelines for human experimentation of the U.S. Department of Health and Human Services and those of Johns Hopkins University and Vanderbilt University were followed in the conduct of these clinical studies.1

Author:

Clements-Mann Mary Lou,Makhene Mamodikoe K,Mrukowicz Jacek,Wright Peter F,Hoshino Yasutaka,Midthun Karen,Sperber Ellen,Karron Ruth,Kapikian Albert Z

Publisher

Elsevier BV

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health,General Veterinary,General Immunology and Microbiology,Molecular Medicine

Reference38 articles.

1. Kapikian AZ, Chanock RM. Rotaviruses. In: Fields BN, Knipe DM, Howley PM et al., editors. Fields Virology, vol. 2. 3rd ed. Philadelphia: Lippincott-Raven Publishers, 1995. p. 1657–1708.

2. The epidemiology of rotavirus diarrhea in the United States: surveillance and estimates of disease burden;Glass;J Infect Dis,1996

3. Impact of diarrheal diseases;Bern,1994

4. Reassortant rotaviruses as potential live rotavirus vaccine candidates;Midthun;J Virol,1985

5. Single gene substitution rotavirus reassortants containing the major neutralization protein (VP7) of human rotavirus serotype 4;Midthun;J Clin Microbiol,1986

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