Chronic local tissue reactions, long term immunogenicity and immunologic priming of mice and guinea pigs to tetanus toxoid encapsulated in biodegradable polymer microspheres composed of poly lactide-co-glycolide polymers

Author:

Gupta Rajesh K.,Alroy Joseph,Alonso Maria J.,Langer Robert,Siber George R.

Publisher

Elsevier BV

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health,General Veterinary,General Immunology and Microbiology,Molecular Medicine

Reference34 articles.

1. Parameters affecting the immunogenicity of microencapsulated tetanus toxoid;Esparza;Vaccine,1992

2. Biodegradable delivery system for single step immunization with tetanus toxoid;Raghuvanshi;International Journal of Pharmaceuticals,1993

3. Development of a single-dose tetanus toxoid based on controlled release from biodegradable and biocompatible polyester microspheres;Gupta,1993

4. Determinants of release rate of tetanus vaccine from polyester microspheres;Alonso;Pharmaceutical Research,1993

5. Immune response to nasal delivery of antigenically intact tetanus toxoid associated with poly(L-lactic acid) microspheres in rats, rabbits and guinea pigs;Almeida;Journal of Pharmaceutical Pharmacology,1993

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