Topical dsRNA challenges may induce overexpression of airway antiviral cytokines in symptomatic allergic disease. A pilot in vivo study in nasal airways

Author:

Brandelius Angelica,Andersson Morgan,Uller Lena

Funder

Swedish Medical Research Council

Heart-and Lung Foundation

VINNOVA- Sweden's Innovation Agency

Publisher

Elsevier BV

Subject

Pulmonary and Respiratory Medicine

Reference11 articles.

1. TLR3: interferon induction by double-stranded RNA including poly(I:C);Matsumoto;Adv Drug Deliv Rev,2008

2. Sensing of viral infection and activation of innate immunity by toll-like receptor 3;Vercammen;Clin Microbiol Rev,2008

3. Selective inhibition by simvastatin of IRF3 phosphorylation and TSLP production in dsRNA-challenged bronchial epithelial cells from COPD donors;Brandelius;Br J Pharmacol,2013

4. Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma;Mahmutovic-Persson;Allergy,2013

5. Are rhinovirus-induced airway responses in asthma aggravated by chronic allergen exposure?;de Kluijver;Am J Respir Crit Care Med,2003

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