A randomized, placebo- and moxifloxacin-controlled thorough QT study of umeclidinium monotherapy and umeclidinium/vilanterol combination in healthy subjects

Author:

Kelleher Dennis,Tombs Lee,Preece Andrew,Brealey Noushin,Mehta Rashmi

Funder

GlaxoSmithKline

Publisher

Elsevier BV

Subject

Pharmacology (medical),Biochemistry (medical),Pulmonary and Respiratory Medicine

Reference35 articles.

1. QT-interval prolongation by non-cardiac drugs: lessons to be learned from recent experience;De Ponti;Eur J Clin Pharmacol,2000

2. Exposure to antibacterial agents with QT liability in 14 European countries: trends over an 8-year period;Raschi;Br J Clin Pharmacol,2009

3. Can pharmacogenetics help rescue drugs withdrawn from the market?;Shah;Pharmacogenomics,2006

4. ICH Topic E14. The clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs;European Medicines Agency,2005

5. Guidance for industry. E14 clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs;US Department of Health and Human Services Food and Drug Administration,2005

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