Freeze-Dryer Equipment Capability Limit: Comparison of Computational Modeling With Experiments at Laboratory Scale

Author:

Shivkumar Gayathri,Kshirsagar Vaibhav,Zhu Tong,Sebastiao Israel B.,Nail Steven L.,Sacha Gregory A.,Alexeenko Alina A.

Funder

Indiana Next Generation Manufacturing Competitiveness Center (IN-MaC)'s Research for Future Competitiveness program for Small to Medium Enterprise (SME) Consortia

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference24 articles.

1. Elements of quality by design in development and scale-up of freeze-dried parenterals;Nail;Biopharm Int,2008

2. Observation and implications of sonic water vapor flow during freeze-drying;Searles;Am Pharm Rev,2004

3. Priciples of lyophilization scale-up;Tchessalov;Am Pharm Rev,2007

4. Choked flow and importance of Mach I in freeze-drying process design;Patel;Chem Eng Sci,2010

5. Computational analysis of fluid dynamics in pharmaceutical freeze-drying;Alexeenko;J Pharm Sci,2009

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