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Chirally Pure Prodrugs and Their Converting Enzymes Lead to High Supersaturation and Rapid Transcellular Permeation of Benzodiazepines

  • Published:2016-08 Issue:8 Volume:105 Page:2365-2371
  • ISSN:0022-3549
  • Container-title:Journal of Pharmaceutical Sciences
  • language:en
  • Short-container-title:Journal of Pharmaceutical Sciences

Author:

Kapoor Mamta,Cheryala Narsihmulu,Rautiola Davin,Georg Gunda I.,Cloyd James C.,Siegel Ronald A.

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference27 articles.

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2. Treatment of convulsive and nonconvulsive status epilepticus;Pang;Curr Treat Options Neurol,2005

3. Development of benzodiazepines for out-of-hospital management of seizure emergencies;Agarwal;Neurol Clin Prac,2014

4. Bioavailability of intranasal vs. rectal diazepam;Ivaturi;Epilepsy Res,2013

5. Intranasal therapies for acute seizures;Kälviäinen;Epilepsy Behav,2015

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1. Inhalable Prodrugs for Pulmonary Therapeutics;Pulmonary Drug Delivery Systems: Material and Technological Advances;2023

2. Experiences in Academic and Industry Partnerships – Forging a Path to Translational Drug Discovery;Burger's Medicinal Chemistry and Drug Discovery;2021-04-28

3. Diazepam Prodrug Stabilizes Human Aminopeptidase B during Lyophilization;Molecular Pharmaceutics;2019-12-26

4. Nasal Spray Device for Administration of Two-Part Drug Formulations;2019 Design of Medical Devices Conference;2019-04-15

5. Intranasal Coadministration of a Diazepam Prodrug with a Converting Enzyme Results in Rapid Absorption of Diazepam in Rats;Journal of Pharmacology and Experimental Therapeutics;2019-03-05
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