Exploratory Investigation of the Limiting Steps of Oral Absorption of Fluconazole and Ketoconazole in Children Using an In Silico Pediatric Absorption Model

Author:

Cristofoletti Rodrigo,Charoo Naseem A.,Dressman Jennifer B.

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference60 articles.

1. Food and Drug Administration (FDA). 2003. Guidance for Industry. Exposure-response relationships–study design, data analysis and regulatory applications. Available at: http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm072109.pdf. Accessed January 10, 2016.

2. Food and Drug Administration (FDA). 2014. Guidance for Industry. General Clinical Pharmacology Considerations for Pediatric Studies for Drugs and Biological Products. Available at: http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm425885.pdf. Accessed January 10, 2016.

3. European Medicines Agency (EMA). 2007. Guideline on the Role of Pharmacokinetics in the Development of medicinal Products in the Paediatric Population. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003066.pdf. Accessed January 10, 2016.

4. Extrapolation of adult data and other data in pediatric drug-development programs;Dunne;Pediatrics,2011

5. Impact of developmental pharmacology on pediatric study design: overcoming the challenges;Kearns;J Allergy Clin Immunol,2000

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