An Unexpected Degradation Pathway of N-Hydroxy-5-Methylfuran-2-Sulfonamide (BMS-986231), a pH Sensitive Prodrug of HNO, in a Prototype Formulation Solution

Author:

Huang YandeORCID,Sarjeant Amy,Sommer Roger,Patel Dhaval,Wang Qinggang,Bindra Dilbir,Miller Scott A.

Publisher

Elsevier BV

Reference7 articles.

1. A phase 2a dose-escalation study of the safety, tolerability, pharmacokinetics and haemodynamic effects of BMS-986231 in hospitalized patients with heart failure with reduced ejection fraction;Tita;Eur J Heart Fail.,2017

2. Intravenous infusion of the novel HNO donor BMS-986231 is associated with beneficial inotropic, lusitropic, and vasodilatory properties in 2 canine models of heart failure;Hartman;JACC: Basic Translat Sci,2018

3. A phase 1 randomized study of single intravenous infusions of the novel nitroxyl donor BMS-986231 in healthy volunteers;Cowart;J Clin Pharmacol,2019

4. Photostability Testing of New Drug Substances and Products,1996

5. Stability Testing of new Drug Substances and Products,2003

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