Molecular Dynamics Simulation to Uncover the Mechanisms of Protein Instability During Freezing
Author:
Publisher
Elsevier BV
Subject
Pharmaceutical Science
Reference94 articles.
1. Influence of controlled ice nucleation on the freeze-drying of pharmaceutical products: the secondary drying step;Oddone;Int J Pharm,2017
2. Impact of buffer, protein concentration and sucrose addition on the aggregation and particle formation during freezing and thawing;Hauptmann;Pharm Res (N Y),2018
3. Distinct aggregation mechanisms of monoclonal antibody under thermal and freeze-thaw stresses revealed by hydrogen exchange;Zhang;Pharma Res,2012
4. Protein and solute distribution in drug substance containers during frozen storage and post-thawing: a tool to understand and define freezing–thawing parameters in biotechnology process development;Kolhe;Biotechnol Prog,2011
5. Freezing bulk-scale biopharmaceuticals using common techniques: and the magnitude of freeze-concentration;Webb;Biopharm (Jilove),2002
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