Comparison of Tumor Binding Across Tumor Types and Cell Lines to Support Free Drug Considerations for Oncology Drug Discovery

Author:

Jordan Samantha,Ryu Sangwoo,Burchett Woodrow,Davis Carl,Jones Rhys,Zhang Sam,Zueva Larisa,Chang GeorgeORCID,Di LiORCID

Funder

Pfizer

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference41 articles.

1. https://www.mckinsey.com/∼/media/McKinsey/Industries/Pharmaceuticals%20and%20Medical%20Products/Our%20Insights/Delivering%20innovation%202020%20oncology%20market%20outlook/Delivering-innovation-2020-oncology-market-outlook-v4.pdf, 2020.

2. Reviving an R&D pipeline: a step change in the Phase II success rate;Wu;Drug Discov Today,2021

3. High drug attrition rates–where are we going wrong?;Hutchinson;Nat Rev Clin Oncol,2011

4. Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical Research;Tuntland;Front Pharmacol,2014

5. The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery;Smith;Nat Rev Drug Discov,2010

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