Large-Scale Freeze-Thaw of Protein Solutions: Study of the Relative Contributions of Freeze-Concentration and Ice Surface Area on Stability of Lactate Dehydrogenase

Author:

Minatovicz Bruna,Sansare SameeraORCID,Mehta Tanu,Bogner Robin H.ORCID,Chaudhuri BodhisattwaORCID

Funder

CPPR

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference48 articles.

1. Freezing and Thawing of Protein Solutions;Singh;Formul Process Dev Strateg Manuf Biopharm,2010

2. Immunogenicity of therapeutic proteins: Clinical implications and future prospects;Schellekens;Clin Ther,2002

3. Study of the individual contributions of ice formation and freeze-concentration on isothermal stability of lactate dehydrogenase during freezing;Bhatnagar;J Pharm Sci,2008

4. Process characterization essentials: process understanding and health authorities guidance;Little;BioPharm Int,2017

5. Protein destabilization at low temperatures;Franks;Adv Protein Chem,1995

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