Development of a chiral HPLC method to evaluate in vivo enantiomeric inversion of an unstable, polar radiosensitizer in plasma-Reference-Cited by-同舟云学术

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Development of a chiral HPLC method to evaluate in vivo enantiomeric inversion of an unstable, polar radiosensitizer in plasma

Published:1999-11 Issue:3 Volume:21 Page:527-534
ISSN:0731-7085
Container-title:Journal of Pharmaceutical and Biomedical Analysis
language:en
Short-container-title:Journal of Pharmaceutical and Biomedical Analysis

Author:

Kagel J.R,Rossi D.T,Hoffman K.L,Leja B,Lathia C.D

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference13 articles.

1. Pharmacokinetic contribution to the improved therapeutic selectivity of a novel bromoethylamino prodrug (RB 6145) of the mixed-function hypoxic cell sensitizer/cytotoxin ?-(1-aziridinomethyl)-2-nitro-1H-imidazole-1-ethanol (RSU 1069)

2. Pharmacokinetics and metabolism of the mixed-function hypoxic cell sensitizer prototype RSU 1069 in mice

3. An HPLC assay utilizing solid-phase extraction for CI-1010, an alkylating radiosensitizer, in rat plasma

4. Modern Synthetic Reactions;House,1972

5. FDA’s Policy Statement for the Development of New Stereochemical Drugs, Chirality 4 (1992) 338–340.

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