Dual Inhibition of MAPK and JAK2/STAT3 Pathways Is Critical for the Treatment of BRAF Mutant Melanoma-Reference-Cited by-同舟云学术

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Dual Inhibition of MAPK and JAK2/STAT3 Pathways Is Critical for the Treatment of BRAF Mutant Melanoma

Published:2020-09 Issue: Volume:18 Page:100-108
ISSN:2372-7705
Container-title:Molecular Therapy - Oncolytics
language:en
Short-container-title:Molecular Therapy - Oncolytics

Author:

Zhao Kun,Lu Yanrong,Chen Younan,Cheng Jingqiu,Zhang Wengeng

Funder

Science and Technology Program, China

Chengdu Science and Technology Program Projects, China

1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University, China

National Natural Science Foundation of China, China

Publisher

Elsevier BV

Subject

Pharmacology (medical),Cancer Research,Oncology,Molecular Medicine

Reference26 articles.

1. Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma;Montagut;Cancer Res.,2008

2. Resistance to selective BRAF inhibition can be mediated by modest upstream pathway activation;Su;Cancer Res.,2012

3. Mutations of the BRAF gene in human cancer;Davies;Nature,2002

4. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF;Wan;Cell,2004

5. Vemurafenib;Garbe;Recent Results Cancer Res.,2018

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