An optimized InCell Western screening technique identifies hexachlorophene as a novel potent TDP43 targeting drug-Reference-Cited by-同舟云学术

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An optimized InCell Western screening technique identifies hexachlorophene as a novel potent TDP43 targeting drug

Published:2015-08 Issue: Volume:207 Page:34-38
ISSN:0168-1656
Container-title:Journal of Biotechnology
language:en
Short-container-title:Journal of Biotechnology

Author:

Narayan Malathi,Peralta Diego A.,Gibson Chelsea,Zitnyar Ashley,Jinwal Umesh K.

Funder

USF College of Pharmacy Dean's Clinical and Pilot Award

Publisher

Elsevier BV

Subject

Applied Microbiology and Biotechnology,General Medicine,Biotechnology,Bioengineering

Reference18 articles.

1. TDP43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis;Arai;Biochem. Biophys. Res. Commun.,2006

2. Structural determinants of the cellular localization and shuttling of TDP43;Ayala;J. Cell Sci.,2008

3. Blocking abeta seeding-mediated aggregation and toxicity in an animal model of Alzheimer's disease: a novel therapeutic strategy for neurodegeneration;Eleuteri;Neurobiol. Dis.,2014

4. Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP43 protein;Jinwal;J. Biol. Chem.,2012

5. Cell-based assays for regulators of tau biology;Jinwal;Methods Mol. Biol.,2011

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