The neuroactive steroid 3α-hydroxy-5β-pregnan-20-one is a two-component modulator of ligand binding to the GABAA receptor

Author:

Hawkinson Jon E.,Kimbrough Catherine L.,McCauley Linda D.,Bolger Michael B.,Lan Nancy C.,Gee Kelvin W.

Publisher

Elsevier BV

Subject

Pharmacology

Reference19 articles.

1. 5α-Pregnan-3α,20a-diol behaves like a partial agonist in the modulation of GABA-stimulated chloride ion uptake by synaptoneurosomes;Belelli;Eur. J. Pharmacol.,1989

2. Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence, and mechanism of action;Gee;J. Pharmacol. Exp. Therap.,1988

3. γ-Aminobutyric acidA receptor complexes in rat frontal cortex and spinal cord show differential responses to steroid modulation;Gee;Mol. Pharmacol.,1991

4. Regional γ-aminobutyric acid sensitivity of t-butylbicyclophosphoro[35S]thionate binding depends on γ-aminobutyric acidA receptor α subunit;Korpi;Mol. Pharmacol.,1993

5. Steroid modulation of the GABAA receptor complex: electrophysiological studies;Lambert,1990

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