Remdesivir triphosphate blocks DNA synthesis and increases exonucleolysis by the replicative mitochondrial DNA polymerase, Pol γ

Author:

Ciesielska Elena J.,Kim Shalom,Bisimwa Hyacintha-ghislaine M.,Grier Cody,Rahman Md. Mostafijur,Young Carolyn K.J.,Young Matthew J.,Oliveira Marcos T.ORCID,Ciesielski Grzegorz L.ORCID

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Molecular Medicine

Reference79 articles.

1. US Food and Drug Administration (2020): Emergency Use Authorization (EUA) for emergency use of remdesivir for the treatment of hospitalized 2019 coronavirus disease (COVID-19) patients. https://www.fda.gov/media/137564/download.

2. Remdesivir: A review of its discovery and development leading to emergency use authorization for treatment of COVID-19;Eastman;ACS Cent. Sci.,2020

3. Remdesivir: Review of pharmacology, pre-clinical data, and emerging clinical experience for COVID-19;Jorgensen;Pharmacotherapy,2020

4. Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency;Gordon;J. Biol. Chem.,2020

5. Mechanism of inhibition of ebola virus RNA-dependent RNA polymerase by remdesivir;Tchesnokov;Viruses,2019

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