Binding of the anticancer drug ZD1694 to E. coli thymidylate synthase: assessing specificity and affinity

Author:

Rutenber Earl E,Stroud Robert M

Publisher

Elsevier BV

Subject

Molecular Biology,Structural Biology

Reference28 articles.

1. Studies on fluorinated pyrimidines: XIII. Inhibition of thymidylate synthase;Hartman;J. Biol. Chem,1958

2. Fluorinated pyrimidines;Heidelberger;Prog. Nucleic Acid Res. Mol. Biol,1965

3. A potent antitumor quinazoline inhibitor of thymidylate synthase: synthesis, biological properties and therapeutic results in mice;Jones;Eur. J. Cancer,1981

4. Biochemical effects of a quinazoline inhibitor of thymidylate synthase, CB3717, on human lymphoblastoid cells;Jackson;Biochem. Pharmacol,1983

5. Activity of the thymidylate synthase inhibitor 2-desamino-N10-propargyl-5,8-dideazafolic acid and related compounds in murine (L1210) and human (W1L2) systems in vitro and in L1210 in vivo;Jackman;Cancer Res,1990

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