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A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity

  • Published:2016-02 Issue:2 Volume:21 Page:250-263
  • ISSN:1359-6446
  • Container-title:Drug Discovery Today
  • language:en
  • Short-container-title:Drug Discovery Today

Author:

Scheer NicoORCID,Wilson Ian D.ORCID

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology

Reference152 articles.

1. Generation and utility of genetically humanized mouse models;Scheer;Drug Discov. Today,2013

2. Humanized mice in translational biomedical research;Shultz;Nat. Rev. Immunol.,2007

3. Species similarities and differences in pharmacokinetics;Lin;Drug Metab. Dispos.,1995

4. Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction;Martignoni;Expert Opin. Drug Metab. Toxicol.,2006

5. Species similarities and differences in pharmacokinetics and distribution of antiretroviral drugs;Owen,2014

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