Can biochemistry drive drug discovery beyond simple potency measurements?

Author:

Chène Patrick

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology

Reference75 articles.

1. Evaluation of Enzyme Inhibitors in Drug Discovery;Copeland,2005

2. Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction;Cheng;Biochem. Pharmacol.,1973

3. Defining balanced conditions for inhibitor screening assays that target bisubstrate enzymes;Yang;J. Biomol. Screen.,2009

4. Factors influencing the inhibition of protein kinases;Brockhoff;J. Enzyme Inhib. Med. Chem.,2011

5. Enzyme Kinetics. Behavior and Analysis of Rapid Equilibrium and Steady-state Enzyme Systems;Segel,1975

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