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Efficient drug discovery by rational lead hybridization based on crystallographic overlay

  • Published:2019-03 Issue:3 Volume:24 Page:805-813
  • ISSN:1359-6446
  • Container-title:Drug Discovery Today
  • language:en
  • Short-container-title:Drug Discovery Today

Author:

Zhang Shuo,Zhang Jian,Gao Ping,Sun Lin,Song Yuning,Kang Dongwei,Liu Xinyong,Zhan Peng

Funder

National Natural Science Foundation of China

Young Scholars Program of Shandong University

Fundamental Research Funds of Shandong University

Key Project of NSFC for International Cooperation

Natural Science Foundation of Shandong Province

Key Research and Development Project of Shandong Province

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology

Reference27 articles.

1. Are antimalarial hybrid molecules a close reality or a distant dream?;Agarwal;Antimicrob. Agents Chemother.,2017

2. Drug evolution concept in drug design: 1. Hybridization method;Lazar;J. Med. Chem.,2004

3. BREED: generating novel inhibitors through hybridization of known ligands. Application to CDK2, p38, and HIV protease;Pierce;J. Med. Chem.,2004

4. Recent advances in the discovery and development of novel HIV-1 NNRTI platforms (Part II): 2009–2013 update;Song;Curr. Med. Chem,2014

5. HIV-1 NNRTIs: structural diversity, pharmacophore similarity, and implications for drug design;Zhan;Med. Res. Rev.,2013
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