Reducing attrition in drug development: smart loading preclinical safety assessment
Author:
Publisher
Elsevier BV
Subject
Drug Discovery,Pharmacology
Reference20 articles.
1. Can the pharmaceutical industry reduce attrition rates?;Kola;Nat. Rev. Drug Discov.,2004
2. The productivity crisis in pharmaceutical R&D;Pammolli;Nat. Rev. Drug Discov.,2011
3. How to improve R&D productivity: the pharmaceutical industry's grand challenge;Paul;Nat. Rev. Drug Discov.,2010
4. The truly staggering cost of inventing new drugs;Herper;Forbes,2012
5. Clinical attrition due to biased preclinical assessments of potential efficacy;Linder;Pharmacol. Ther.,2007
Cited by 78 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Assessing the interplay between off-target promiscuity, cytotoxicity, and tolerability in rodents to improve the safety profile of novel anti-malarial plasmepsin X inhibitors;Toxicological Sciences;2024-07-08
2. Recent advances in protein precipitation-based methods for drug-target screening;Chinese Journal of Chromatography;2024-07-01
3. Binding Promiscuity of Therapeutic Factor VIII;Thrombosis and Haemostasis;2024-07-01
4. A 3D spheroid model of quadruple cell co-culture with improved liver functions for hepatotoxicity prediction;Toxicology;2024-06
5. Electrophysiological Changes in the Rabbit Ventricular Wedge and Human-Induced Pluripotent Stem-Cell Derived (IPSC) Cardiomyocytes Translate to Severe Arrhythmia Observed in a Canine Toxicology Study, Not Predicted by Standard In Vitro Ion Channel Assays;International Journal of Toxicology;2024-02-08
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3