Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood–brain barrier: kinetics and metabolism in the rat

Author:

Luurtsema Gert,Molthoff Carla F.M.,Schuit Robert C.,Windhorst Albert D.,Lammertsma Adriaan A.,Franssen Eric J.F.

Publisher

Elsevier BV

Subject

Cancer Research,Radiology Nuclear Medicine and imaging,Molecular Medicine

Reference42 articles.

1. Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans;Vogelgesang;Pharmacogenetics,2002

2. Pharmacogenomics—drug disposition, drug targets, and side effects;Evans;New Engl. J. Med.,2003

3. In vivo measurement of [11C]verapamil kinetics in human tissues;Hendrikse;Eur. J. Clin. Pharmacol.,2001

4. Quantitative estimation of P-glycoprotein in transport using [11C]verapamil;Muzi;J. Nucl. Med. Suppl.,2003

5. Clinical pharmacokinetics of verapamil, nifedipine and diltiazem;Echizen;Clin. Pharmacokinet.,1986

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