Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins

Author:

Shirasaki Ryosuke,Matthews Geoffrey M.,Gandolfi SaraORCID,de Matos Simoes Ricardo,Buckley Dennis L.,Raja Vora JoselineORCID,Sievers Quinlan L.,Brüggenthies Johanna B.,Dashevsky Olga,Poarch Haley,Tang Huihui,Bariteau Megan A.,Sheffer Michal,Hu Yiguo,Downey-Kopyscinski Sondra L.,Hengeveld Paul J.ORCID,Glassner Brian J.,Dhimolea Eugen,Ott Christopher J.,Zhang Tinghu,Kwiatkowski Nicholas P.,Laubach Jacob P.,Schlossman Robert L.,Richardson Paul G.,Culhane Aedin C.ORCID,Groen Richard W.J.,Fischer Eric S.,Vazquez Francisca,Tsherniak AviadORCID,Hahn William C.,Levy Joan,Auclair Daniel,Licht Jonathan D.,Keats Jonathan J.,Boise Lawrence H.,Ebert Benjamin L.,Bradner James E.,Gray Nathanael S.,Mitsiades Constantine S.

Funder

University of Texas MD Anderson Cancer Center

Chambers Family Fund

U.S. Department of Defense

Ludwig Center at Harvard

Damon Runyon Cancer Research Foundation

National Institute of General Medical Sciences

National Institutes of Health

Lauri Strauss Leukemia Foundation

Leukemia and Lymphoma Society

Multiple Myeloma Research Foundation

American Australian Association

International Myeloma Foundation

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference75 articles.

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2. Catalytic in vivo protein knockdown by small-molecule PROTACs;Bondeson;Nat. Chem. Biol.,2015

3. Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead;Bondeson;Cell Chem. Biol.,2018

4. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins;Buckley;ACS Chem. Biol.,2015

5. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study;Burslem;Cell Chem. Biol.,2018

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