HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer

Author:

Brunton HollyORCID,Caligiuri Giuseppina,Cunningham Richard,Upstill-Goddard Rosie,Bailey Ulla-Maja,Garner Ian M.,Nourse Craig,Dreyer Stephan,Jones Marc,Moran-Jones Kim,Wright Derek W.,Paulus-Hock Viola,Nixon Colin,Thomson Gemma,Jamieson Nigel B.,McGregor Grant A.,Evers Lisa,McKay Colin J.,Gulati Aditi,Brough Rachel,Bajrami Ilirjana,Pettitt Stephen J.,Dziubinski Michele L.,Barry Simon T.,Grützmann Robert,Brown Robert,Curry Edward,Pajic Marina,Musgrove Elizabeth A.,Petersen Gloria M.,Shanks Emma,Ashworth Alan,Crawford Howard C.,Simeone Diane M.,Froeling Fieke E.M.,Lord Christopher J.,Mukhopadhyay Debabrata,Pilarsky Christian,Grimmond Sean E.,Morton Jennifer P.,Sansom Owen J.,Chang David K.,Bailey Peter J.,Biankin Andrew V.,Allison Sarah,Biankin Andrew V.,Chang David K.,Cooke Susanna L.,Dreyer Stephan,Grimwood Paul,Kelly Shane,Marshall John,McDade Brian,McElroy Daniel,Ramsay Donna,Upstill-Goddard Rosie,Rebus Selma,Hair Jane,Jamieson Nigel B.,McKay Colin J.,Westwood Paul,Williams Nicola,Duthie Fraser,Biankin Andrew V.,Johns Amber L.,Mawson Amanda,Chang David K.,Scarlett Christopher J.,Brancato Mary-Anne L.,Rowe Sarah J.,Simpson Skye H.,Martyn-Smith Mona,Thomas Michelle T.,Chantrill Lorraine A.,Chin Venessa T.,Chou Angela,Cowley Mark J.,Humphris Jeremy L.,Mead R. Scott,Nagrial Adnan M.,Pajic Marina,Pettit Jessica,Pinese Mark,Rooman Ilse,Wu Jianmin,Tao Jiang,DiPietro Renee,Watson Clare,Steinmann Angela,Lee Hong Ching,Wong Rachel,Pinho Andreia V.,Giry-Laterriere Marc,Daly Roger J.,Musgrove Elizabeth A.,Sutherland Robert L.,Grimmond Sean M.,Waddell Nicola,Kassahn Karin S.,Miller David K.,Wilson Peter J.,Patch Ann-Marie,Song Sarah,Harliwong Ivon,Idrisoglu Senel,Nourbakhsh Ehsan,Manning Suzanne,Wani Shivangi,Gongora Milena,Anderson Matthew,Holmes Oliver,Leonard Conrad,Taylor Darrin,Wood Scott,Xu Christina,Nones Katia,Fink J. Lynn,Christ Angelika,Bruxner Tim,Cloonan Nicole,Newell Felicity,Pearson John V.,Quinn Michael,Nagaraj Shivashankar,Kazakoff Stephen,Waddell Nick,Krisnan Keerthana,Quek Kelly,Wood David,Samra Jaswinder S.,Gill Anthony J.,Pavlakis Nick,Guminski Alex,Toon Christopher,Asghari Ray,Merrett Neil D.,Pavey Darren,Das Amitabha,Cosman Peter H.,Ismail Kasim,O’Connnor Chelsie,Lam Vincent W.,McLeod Duncan,Pleass Henry C.,Richardson Arthur,James Virginia,Kench James G.,Cooper Caroline L.,Joseph David,Sandroussi Charbel,Crawford Michael,Gallagher James,Texler Michael,Forest Cindy,Laycock Andrew,Epari Krishna P.,Ballal Mo,Fletcher David R.,Mukhedkar Sanjay,Spry Nigel A.,DeBoer Bastiaan,Chai Ming,Zeps Nikolajs,Beilin Maria,Feeney Kynan,Nguyen Nan Q.,Ruszkiewicz Andrew R.,Worthley Chris,Tan Chuan P.,Debrencini Tamara,Chen John,Brooke-Smith Mark E.,Papangelis Virginia,Tang Henry,Barbour Andrew P.,Clouston Andrew D.,Martin Patrick,O’Rourke Thomas J.,Chiang Amy,Fawcett Jonathan W.,Slater Kellee,Yeung Shinn,Hatzifotis Michael,Hodgkinson Peter,Christophi Christopher,Nikfarjam Mehrdad,Mountain Angela,Eshleman James R.,Hruban Ralph H.,Maitra Anirban,Iacobuzio-Donahue Christine A.,Schulick Richard D.,Wolfgang Christopher L.,Morgan Richard A.,Hodgin Mary,Scarpa Aldo,Lawlor Rita T.,Beghelli Stefania,Corbo Vincenzo,Scardoni Maria,Bassi Claudio,Tempero Margaret A.,Nourse Craig,Jamieson Nigel B.,Graham Janet S.

Funder

National Health and Medical Research Council of Australia

American Association for Cancer Research

Landon Foundation

Susan Wojcicki and Dennis Tropper NIH

NIH

NHMRC

Cancer Australia

Cancer Research UK

Wellcome Trust Senior Investigator Award

Pancreatic Cancer UK Future Research Leaders Fund

Scottish Genome Partnership

Pancreatic Cancer Research Fund

MRC/EPSRC Glasgow Molecular Pathology Node

The Howat Foundation

Italian Cancer Genome Project–Ministry of University

Associazione Italiana Ricerca Cancro

FP7 European Community Grant Cam-Pac

Italian Ministry of Health

ICGC Ontario Institute for Cancer Research

Australian Pancreatic Cancer Genome Initiative

Garvin Institute of Medical Research

CRUK Glasgow Centre

Core Services at the Cancer Research UK Beatson Institute

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

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