The Alzheimer’s Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides-Reference-Cited by-同舟云学术

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The Alzheimer’s Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides

Published:2017-06 Issue:10 Volume:19 Page:1967-1976
ISSN:2211-1247
Container-title:Cell Reports
language:en
Short-container-title:Cell Reports

Author:

Siegel Gabriele,Gerber Hermeto,Koch Philipp,Bruestle Oliver,Fraering Patrick C.,Rajendran Lawrence

Funder

Swiss National Science Foundation (SNF

Velux Foundation

Novartis Foundation

Bangerter Stiftung

Baugarten Stiftung

Synapsis Foundation

SNF

Strauss Foundation

German Federal Ministry for Education and Research

EMBO

University of Zurich’s Forschungskredit

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference48 articles.

1. Signature amyloid β profiles are produced by different γ-secretase complexes;Acx;J. Biol. Chem.,2014

2. Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor?;Beel;Biochemistry,2008

3. Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain;Bolduc;Proc. Natl. Acad. Sci. USA,2016

4. Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer’s disease;Cacquevel;J. Neurochem.,2008

5. BACE1 is the major beta-secretase for generation of Abeta peptides by neurons;Cai;Nat. Neurosci.,2001

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