Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis

Author:

Hollinshead Kate E.R.,Munford Haydn,Eales Katherine L.,Bardella Chiara,Li Chunjie,Escribano-Gonzalez Cristina,Thakker Alpesh,Nonnenmacher Yannic,Kluckova Katarina,Jeeves Mark,Murren Robert,Cuozzo Federica,Ye Dan,Laurenti Giulio,Zhu Wei,Hiller Karsten,Hodson David J.,Hua Wei,Tomlinson Ian P.,Ludwig Christian,Mao Ying,Tennant Daniel A.

Funder

BBSRC

AstraZeneca

Brain Tumour Charity

Medical Research Council

Program of International Science & Technology Cooperation of China

973 Program

Shanghai Committee of Science and Technology

National Natural Science Foundation of China

Diabetes UK R.D. Lawrence

EFSD/Novo Nordisk Rising Star

Wellcome Trust

MRC

European Research Council

European Union’s Horizon 2020 Research and Innovation Programme

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

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