Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma-Reference-Cited by-同舟云学术

Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma

Published:2016-01 Issue:3 Volume:14 Page:598-610
ISSN:2211-1247
Container-title:Cell Reports
language:en
Short-container-title:Cell Reports

Author:

Grohar Patrick J.,Kim Suntae,Rangel Rivera Guillermo O.,Sen Nirmalya,Haddock Sara,Harlow Matt L.,Maloney Nichole K.,Zhu Jack,O’Neill Maura,Jones Tamara L.,Huppi Konrad,Grandin Magdalena,Gehlhaus Kristen,Klumpp-Thomas Carleen A.,Buehler Eugen,Helman Lee J.,Martin Scott E.,Caplen Natasha J.

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference38 articles.

1. DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma;Bailly;Mol. Cell. Biol.,1994

2. Genomic EWS-FLI1 fusion sequences in Ewing sarcoma resemble breakpoint characteristics of immature lymphoid malignancies;Berger;PLoS ONE,2013

3. Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer;Bilke;Genome Res.,2013

4. The spliceosome as a target of novel antitumour drugs;Bonnal;Nat. Rev. Drug Discov.,2012

5. The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation;Brohl;PLoS Genet.,2014

Cited by 39 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Stabilizing mammalian RNA thermometer confers neuroprotection in subarachnoid hemorrhage;2024-05-17

2. ETS1, a Target Gene of the EWSR1::FLI1 Fusion Oncoprotein, Regulates the Expression of the Focal Adhesion Protein TENSIN3;Molecular Cancer Research;2024-04-08

3. Cell Context Is the Third Axis of Synergy for the Combination of ATR Inhibition and Cisplatin in Ewing Sarcoma;Clinical Cancer Research;2024-03-20

4. Endogenous EWSR1 Exists in Two Visual Modalities That Reflect Its Associations with Nucleic Acids and Concentration at Sites of Active Transcription;Molecular and Cellular Biology;2024-03-03

5. Advances in RNA therapeutics for modulation of ‘undruggable’ targets;Progress in Molecular Biology and Translational Science;2024