MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia-Reference-Cited by-同舟云学术

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

Published:2017-01 Issue:2 Volume:18 Page:482-495
ISSN:2211-1247
Container-title:Cell Reports
language:en
Short-container-title:Cell Reports

Author:

Kerry Jon,Godfrey Laura,Repapi Emmanouela,Tapia Marta,Blackledge Neil P.,Ma Helen,Ballabio Erica,O’Byrne Sorcha,Ponthan Frida,Heidenreich Olaf,Roy Anindita,Roberts Irene,Konopleva Marina,Klose Robert J.,Geng Huimin,Milne Thomas A.

Funder

Medical Research Council (MRC, UK) Molecular Haematology Unit

National Institute for Health Research

Oxford Biomedical Research Centre

UCSF Academic Senate

European Research Council Consolidator

Wellcome Trust Senior Research Fellowship

Bloodwise

Clinician Scientist Fellowship

EHA-ASH Translational Research Training in Hematology Fellowship

University of Oxford

NIHR

Cancer Research UK

Wellcome Trust

MRC

Joint MRC/Wellcome Trust

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

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4. MLL-rearranged acute lymphoblastic leukemias activate BCL-2 through H3K79 methylation and are sensitive to the BCL-2-specific antagonist ABT-199;Benito;Cell Rep.,2015

5. MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L;Bernt;Cancer Cell,2011

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