ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation

Author:

Monypenny James,Milewicz Hanna,Flores-Borja Fabian,Weitsman Gregory,Cheung Anthony,Chowdhury Ruhe,Burgoyne Thomas,Arulappu Appitha,Lawler Katherine,Barber Paul R.,Vicencio Jose M.,Keppler Melanie,Wulaningsih Wahyu,Davidson Sean M.,Fraternali Franca,Woodman Natalie,Turmaine Mark,Gillett Cheryl,Franz Dafne,Quezada Sergio A.,Futter Clare E.,Von Kriegsheim Alex,Kolch Walter,Vojnovic Borivoj,Carlton Jeremy G.,Ng Tony

Funder

Cancer Research UK

King’s College London-UCL Comprehensive Cancer Imaging Centre

MRC

DoH

EU FP7

KCL Breast Cancer Now Unit

Wellcome Trust

Dimbleby Cancer Care

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference37 articles.

1. 136O: Osimertinib combined with durvalumab in EGFR-mutant non-small cell lung cancer: Results from the TATTON phase Ib trial;Ahn;J. Thorac. Oncol.,2016

2. Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors;Akbay;Cancer Discov.,2013

3. Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor;Aslakson;Cancer Res.,1992

4. Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer;Azuma;Ann. Oncol.,2014

5. Syndecan-syntenin-ALIX regulates the biogenesis of exosomes;Baietti;Nat. Cell Biol.,2012

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