TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis

Author:

Willemsen Joschka,Neuhoff Marie-Therese,Hoyler Thomas,Noir Emma,Tessier Clemence,Sarret Sophie,Thorsen Tara N.,Littlewood-Evans Amanda,Zhang Juan,Hasan Maroof,Rush James S.,Guerini Danilo,Siegel Richard M.

Funder

Novartis Institutes for BioMedical Research

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference74 articles.

1. Interleukin-1β induces mtDNA release to activate innate immune signaling via cGAS-STING;Aarreberg;Mol. Cell,2019

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3. Inflammatory bowel disease pathobiology: the role of the interferon signature;Andreou;Ann. Gastroenterol.,2020

4. Vitamin D cell signalling in health and disease;Berridge;Biochem. Biophys. Res. Commun.,2015

5. IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes: JAKinibs suppress the interferon response in RA-FLSs;Bonelli;Exp. Mol. Med.,2019

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