Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7

Author:

Meng Bo,Kemp Steven A.,Papa Guido,Datir Rawlings,Ferreira Isabella A.T.M.,Marelli Sara,Harvey William T.,Lytras Spyros,Mohamed Ahmed,Gallo Giulia,Thakur Nazia,Collier Dami A.,Mlcochova Petra,Duncan Lidia M.,Carabelli Alessandro M.,Kenyon Julia C.,Lever Andrew M.,De Marco Anna,Saliba Christian,Culap Katja,Cameroni Elisabetta,Matheson Nicholas J.,Piccoli Luca,Corti Davide,James Leo C.,Robertson David L.,Bailey Dalan,Gupta Ravindra K.,Robson Samuel C.,Loman Nicholas J.,Connor Thomas R.,Golubchik Tanya,Martinez Nunez Rocio T.,Ludden Catherine,Corden Sally,Johnston Ian,Bonsall David,Smith Colin P.,Awan Ali R.,Bucca Giselda,Torok M. Estee,Saeed Kordo,Prieto Jacqui A.,Jackson David K.,Hamilton William L.,Snell Luke B.,Moore Catherine,Harrison Ewan M.,Goncalves Sonia,Fairley Derek J.,Loose Matthew W.,Watkins Joanne,Livett Rich,Moses Samuel,Amato Roberto,Nicholls Sam,Bull Matthew,Smith Darren L.,Barrett Jeff,Aanensen David M.,Curran Martin D.,Parmar Surendra,Aggarwal Dinesh,Shepherd James G.,Parker Matthew D.,Glaysher Sharon,Bashton Matthew,Underwood Anthony P.,Pacchiarini Nicole,Loveson Katie F.,Templeton Kate E.,Langford Cordelia F.,Sillitoe John,de Silva Thushan I.,Wang Dennis,Kwiatkowski Dominic,Rambaut Andrew,O’Grady Justin,Cottrell Simon,Holden Matthew T.G.,Thomson Emma C.,Osman Husam,Andersson Monique,Chauhan Anoop J.,Hassan-Ibrahim Mohammed O.,Lawniczak Mara,Alderton Alex,Chand Meera,Constantinidou Chrystala,Unnikrishnan Meera,Darby Alistair C.,Hiscox Julian A.,Paterson Steve,Martincorena Inigo,Volz Erik M.,Page Andrew J.,Pybus Oliver G.,Bassett Andrew R.,Ariani Cristina V.,Chapman Michael H. Spencer,Li Kathy K.,Shah Rajiv N.,Jesudason Natasha G.,Taha Yusri,McHugh Martin P.,Dewar Rebecca,Jahun Aminu S.,McMurray Claire,Pandey Sarojini,McKenna James P.,Nelson Andrew,Young Gregory R.,McCann Clare M.,Elliott Scott,Lowe Hannah,Temperton Ben,Roy Sunando,Price Anna,Rey Sara,Wyles Matthew,Rooke Stefan,Shaaban Sharif,de Cesare Mariateresa,Letchford Laura,Silveira Siona,Pelosi Emanuela,Wilson-Davies Eleri,Hosmillo Myra,O’Toole Áine,Hesketh Andrew R.,Stark Richard,du Plessis Louis,Ruis Chris,Adams Helen,Bourgeois Yann,Michell Stephen L.,Gramatopoulos Dimitris,Edgeworth Jonathan,Breuer Judith,Todd John A.,Fraser Christophe,Buck David,John Michaela,Kay Gemma L.,Palmer Steve,Peacock Sharon J.,Heyburn David,Weldon Danni,Robinson Esther,McNally Alan,Muir Peter,Vipond Ian B.,Boyes John,Sivaprakasam Venkat,Salluja Tranprit,Dervisevic Samir,Meader Emma J.,Park Naomi R.,Oliver Karen,Jeffries Aaron R.,Ott Sascha,da Silva Filipe Ana,Simpson David A.,Williams Chris,Masoli Jane A.H.,Knight Bridget A.,Jones Christopher R.,Koshy Cherian,Ash Amy,Casey Anna,Bosworth Andrew,Ratcliffe Liz,Xu-McCrae Li,Pymont Hannah M.,Hutchings Stephanie,Berry Lisa,Jones Katie,Halstead Fenella,Davis Thomas,Holmes Christopher,Iturriza-Gomara Miren,Lucaci Anita O.,Randell Paul Anthony,Cox Alison,Madona Pinglawathee,Harris Kathryn Ann,Brown Julianne Rose,Mahungu Tabitha W.,Irish-Tavares Dianne,Haque Tanzina,Hart Jennifer,Witele Eric,Fenton Melisa Louise,Liggett Steven,Graham Clive,Swindells Emma,Collins Jennifer,Eltringham Gary,Campbell Sharon,McClure Patrick C.,Clark Gemma,Sloan Tim J.,Jones Carl,Lynch Jessica,Warne Ben,Leonard Steven,Durham Jillian,Williams Thomas,Haldenby Sam T.,Storey Nathaniel,Alikhan Nabil-Fareed,Holmes Nadine,Moore Christopher,Carlile Matthew,Perry Malorie,Craine Noel,Lyons Ronan A.,Beckett Angela H.,Goudarzi Salman,Fearn Christopher,Cook Kate,Dent Hannah,Paul Hannah,Davies Robert,Blane Beth,Girgis Sophia T.,Beale Mathew A.,Bellis Katherine L.,Dorman Matthew J.,Drury Eleanor,Kane Leanne,Kay Sally,McGuigan Samantha,Nelson Rachel,Prestwood Liam,Rajatileka Shavanthi,Batra Rahul,Williams Rachel J.,Kristiansen Mark,Green Angie,Justice Anita,Mahanama Adhyana I.K.,Samaraweera Buddhini,Hadjirin Nazreen F.,Quick Joshua,Poplawski Radoslaw,Kermack Leanne M.,Reynolds Nicola,Hall Grant,Chaudhry Yasmin,Pinckert Malte L.,Georgana Iliana,Moll Robin J.,Thornton Alicia,Myers Richard,Stockton Joanne,Williams Charlotte A.,Yew Wen C.,Trotter Alexander J.,Trebes Amy,MacIntyre-Cockett George,Birchley Alec,Adams Alexander,Plimmer Amy,Gatica-Wilcox Bree,McKerr Caoimhe,Hilvers Ember,Jones Hannah,Asad Hibo,Coombes Jason,Evans Johnathan M.,Fina Laia,Gilbert Lauren,Graham Lee,Cronin Michelle,Kumziene-Summerhayes Sara,Taylor Sarah,Jones Sophie,Groves Danielle C.,Zhang Peijun,Gallis Marta,Louka Stavroula F.,Starinskij Igor,Jackson Chris,Gourtovaia Marina,Tonkin-Hill Gerry,Lewis Kevin,Tovar-Corona Jaime M.,James Keith,Baxter Laura,Alam Mohammad T.,Orton Richard J.,Hughes Joseph,Vattipally Sreenu,Ragonnet-Cronin Manon,Nascimento Fabricia F.,Jorgensen David,Boyd Olivia,Geidelberg Lily,Zarebski Alex E.,Raghwani Jayna,Kraemer Moritz U.G.,Southgate Joel,Lindsey Benjamin B.,Freeman Timothy M.,Keatley Jon-Paul,Singer Joshua B.,de Oliveira Martins Leonardo,Yeats Corin A.,Abudahab Khalil,Taylor Ben E.W.,Menegazzo Mirko,Danesh John,Hogsden Wendy,Eldirdiri Sahar,Kenyon Anita,Mason Jenifer,Robinson Trevor I.,Holmes Alison,Price James,Hartley John A.,Curran Tanya,Mather Alison E.,Shankar Giri,Jones Rachel,Howe Robin,Morgan Sian,Wastenge Elizabeth,Chapman Michael R.,Mookerjee Siddharth,Stanley Rachael,Smith Wendy,Peto Timothy,Eyre David,Crook Derrick,Vernet Gabrielle,Kitchen Christine,Gulliver Huw,Merrick Ian,Guest Martyn,Munn Robert,Bradley Declan T.,Wyatt Tim,Beaver Charlotte,Foulser Luke,Palmer Sophie,Churcher Carol M.,Brooks Ellena,Smith Kim S.,Galai Katerina,McManus Georgina M.,Bolt Frances,Coll Francesc,Meadows Lizzie,Attwood Stephen W.,Davies Alisha,De Lacy Elen,Downing Fatima,Edwards Sue,Scarlett Garry P.,Jeremiah Sarah,Smith Nikki,Leek Danielle,Sridhar Sushmita,Forrest Sally,Cormie Claire,Gill Harmeet K.,Dias Joana,Higginson Ellen E.,Maes Mailis,Young Jamie,Wantoch Michelle,Jamrozy Dorota,Lo Stephanie,Patel Minal,Hill Verity,Bewshea Claire M.,Ellard Sian,Auckland Cressida,Harrison Ian,Bishop Chloe,Chalker Vicki,Richter Alex,Beggs Andrew,Best Angus,Percival Benita,Mirza Jeremy,Megram Oliver,Mayhew Megan,Crawford Liam,Ashcroft Fiona,Moles-Garcia Emma,Cumley Nicola,Hopes Richard,Asamaphan Patawee,Niebel Marc O.,Gunson Rory N.,Bradley Amanda,Maclean Alasdair,Mollett Guy,Blacow Rachel,Bird Paul,Helmer Thomas,Fallon Karlie,Tang Julian,Hale Antony D.,Macfarlane-Smith Louissa R.,Harper Katherine L.,Carden Holli,Machin Nicholas W.,Jackson Kathryn A.,Ahmad Shazaad S.Y.,George Ryan P.,Turtle Lance,O’Toole Elaine,Watts Joanne,Breen Cassie,Cowell Angela,Alcolea-Medina Adela,Charalampous Themoula,Patel Amita,Levett Lisa J.,Heaney Judith,Rowan Aileen,Taylor Graham P.,Shah Divya,Atkinson Laura,Lee Jack C.D.,Westhorpe Adam P.,Jannoo Riaz,Lowe Helen L.,Karamani Angeliki,Ensell Leah,Chatterton Wendy,Pusok Monika,Dadrah Ashok,Symmonds Amanda,Sluga Graciela,Molnar Zoltan,Baker Paul,Bonner Stephen,Essex Sarah,Barton Edward,Padgett Debra,Scott Garren,Greenaway Jane,Payne Brendan A.I.,Burton-Fanning Shirelle,Waugh Sheila,Raviprakash Veena,Sheriff Nicola,Blakey Victoria,Williams Lesley-Anne,Moore Jonathan,Stonehouse Susanne,Smith Louise,Davidson Rose K.,Bedford Luke,Coupland Lindsay,Wright Victoria,Chappell Joseph G.,Tsoleridis Theocharis,Ball Jonathan,Khakh Manjinder,Fleming Vicki M.,Lister Michelle M.,Howson-Wells Hannah C.,Berry Louise,Boswell Tim,Joseph Amelia,Willingham Iona,Duckworth Nichola,Walsh Sarah,Wise Emma,Moore Nathan,Mori Matilde,Cortes Nick,Kidd Stephen,Williams Rebecca,Gifford Laura,Bicknell Kelly,Wyllie Sarah,Lloyd Allyson,Impey Robert,Malone Cassandra S.,Cogger Benjamin J.,Levene Nick,Monaghan Lynn,Keeley Alexander J.,Partridge David G.,Raza Mohammad,Evans Cariad,Johnson Kate,Betteridge Emma,Farr Ben W.,Goodwin Scott,Quail Michael A.,Scott Carol,Shirley Lesley,Thurston Scott A.J.,Rajan Diana,Bronner Iraad F.,Aigrain Louise,Redshaw Nicholas M.,Lensing Stefanie V.,McCarthy Shane,Makunin Alex,Balcazar Carlos E.,Gallagher Michael D.,Williamson Kathleen A.,Stanton Thomas D.,Michelsen Michelle L.,Warwick-Dugdale Joanna,Manley Robin,Farbos Audrey,Harrison James W.,Sambles Christine M.,Studholme David J.,Lackenby Angie,Mbisa Tamyo,Platt Steven,Miah Shahjahan,Bibby David,Manso Carmen,Hubb Jonathan,Dabrera Gavin,Ramsay Mary,Bradshaw Daniel,Schaefer Ulf,Groves Natalie,Gallagher Eileen,Lee David,Williams David,Ellaby Nicholas,Hartman Hassan,Manesis Nikos,Patel Vineet,Ledesma Juan,Twohig Katherine A.,Allara Elias,Pearson Clare,Cheng Jeffrey K.J.,Bridgewater Hannah E.,Frost Lucy R.,Taylor-Joyce Grace,Brown Paul E.,Tong Lily,Broos Alice,Mair Daniel,Nichols Jenna,Carmichael Stephen N.,Smollett Katherine L.,Nomikou Kyriaki,Aranday-Cortes Elihu,Johnson Natasha,Nickbakhsh Seema,Vamos Edith E.,Hughes Margaret,Rainbow Lucille,Eccles Richard,Nelson Charlotte,Whitehead Mark,Gregory Richard,Gemmell Matthew,Wierzbicki Claudia,Webster Hermione J.,Fisher Chloe L.,Signell Adrian W.,Betancor Gilberto,Wilson Harry D.,Nebbia Gaia,Flaviani Flavia,Cerda Alberto C.,Merrill Tammy V.,Wilson Rebekah E.,Cotic Marius,Bayzid Nadua,Thompson Thomas,Acheson Erwan,Rushton Steven,O’Brien Sarah,Baker David J.,Rudder Steven,Aydin Alp,Sang Fei,Debebe Johnny,Francois Sarah,Vasylyeva Tetyana I.,Zamudio Marina Escalera,Gutierrez Bernardo,Marchbank Angela,Maksimovic Joshua,Spellman Karla,McCluggage Kathryn,Morgan Mari,Beer Robert,Afifi Safiah,Workman Trudy,Fuller William,Bresner Catherine,Angyal Adrienn,Green Luke R.,Parsons Paul J.,Tucker Rachel M.,Brown Rebecca,Whiteley Max,Bonfield James,Puethe Christoph,Whitwham Andrew,Liddle Jennifier,Rowe Will,Siveroni Igor,Le-Viet Thanh,Gaskin Amy,Johnson Rob,Abnizova Irina,Ali Mozam,Allen Laura,Anderson Ralph,Ariani Cristina,Austin-Guest Siobhan,Bala Sendu,Barrett Jeffrey,Bassett Andrew,Battleday Kristina,Beal James,Beale Mathew,Bellany Sam,Bellerby Tristram,Bellis Katie,Berger Duncan,Berriman Matt,Bevan Paul,Binley Simon,Bishop Jason,Blackburn Kirsty,Boughton Nick,Bowker Sam,Brendler-Spaeth Timothy,Bronner Iraad,Brooklyn Tanya,Buddenborg Sarah Kay,Bush Robert,Caetano Catarina,Cagan Alex,Carter Nicola,Cartwright Joanna,Monteiro Tiago Carvalho,Chapman Liz,Chillingworth Tracey-Jane,Clapham Peter,Clark Richard,Clarke Adrian,Clarke Catriona,Cole Daryl,Cook Elizabeth,Coppola Maria,Cornell Linda,Cornwell Clare,Corton Craig,Crackett Abby,Cranage Alison,Craven Harriet,Craw Sarah,Crawford Mark,Cutts Tim,Dabrowska Monika,Davies Matt,Dawson Joseph,Day Callum,Densem Aiden,Dibling Thomas,Dockree Cat,Dodd David,Dogga Sunil,Dorman Matthew,Dougan Gordon,Dougherty Martin,Dove Alexander,Drummond Lucy,Dudek Monika,Durrant Laura,Easthope Elizabeth,Eckert Sabine,Ellis Pete,Farr Ben,Fenton Michael,Ferrero Marcella,Flack Neil,Fordham Howerd,Forsythe Grace,Francis Matt,Fraser Audrey,Freeman Adam,Galvin Anastasia,Garcia-Casado Maria,Gedny Alex,Girgis Sophia,Glover James,Gould Oliver,Gray Andy,Gray Emma,Griffiths Coline,Gu Yong,Guerin Florence,Hamilton Will,Hanks Hannah,Harrison Ewan,Harrott Alexandria,Harry Edward,Harvison Julia,Heath Paul,Hernandez-Koutoucheva Anastasia,Hobbs Rhiannon,Holland Dave,Holmes Sarah,Hornett Gary,Hough Nicholas,Huckle Liz,Hughes-Hallet Lena,Hunter Adam,Inglis Stephen,Iqbal Sameena,Jackson Adam,Jackson David,Verdejo Carlos Jimenez,Jones Matthew,Kallepally Kalyan,Kay Keely,Keatley Jon,Keith Alan,King Alison,Kitchin Lucy,Kleanthous Matt,Klimekova Martina,Korlevic Petra,Krasheninnkova Ksenia,Lane Greg,Langford Cordelia,Laverack Adam,Law Katharine,Lensing Stefanie,Lewis-Wade Amanah,Liddle Jennifer,Lin Quan,Lindsay Sarah,Linsdell Sally,Long Rhona,Lovell Jamie,Lovell Jon,Mack James,Maddison Mark,Makunin Aleksei,Mamun Irfan,Mansfield Jenny,Marriott Neil,Martin Matt,Mayho Matthew,McClintock Jo,McHugh Sandra,MapcMinn Liz,Meadows Carl,Mobley Emily,Moll Robin,Morra Maria,Morrow Leanne,Murie Kathryn,Nash Sian,Nathwani Claire,Naydenova Plamena,Neaverson Alexandra,Nerou Ed,Nicholson Jon,Nimz Tabea,Noell Guillaume G.,O’Meara Sarah,Ohan Valeriu,Olney Charles,Ormond Doug,Oszlanczi Agnes,Pang Yoke Fei,Pardubska Barbora,Park Naomi,Parmar Aaron,Patel Gaurang,Payne Maggie,Peacock Sharon,Petersen Arabella,Plowman Deborah,Preston Tom,Quail Michael,Rance Richard,Rawlings Suzannah,Redshaw Nicholas,Reynolds Joe,Reynolds Mark,Rice Simon,Richardson Matt,Roberts Connor,Robinson Katrina,Robinson Melanie,Robinson David,Rogers Hazel,Rojo Eduardo Martin,Roopra Daljit,Rose Mark,Rudd Luke,Sadri Ramin,Salmon Nicholas,Saul David,Schwach Frank,Seekings Phil,Simms Alison,Sinnott Matt,Sivadasan Shanthi,Siwek Bart,Sizer Dale,Skeldon Kenneth,Skelton Jason,Slater-Tunstill Joanna,Sloper Lisa,Smerdon Nathalie,Smith Chris,Smith Christen,Smith James,Smith Katie,Smith Michelle,Smith Sean,Smith Tina,Sneade Leighton,Soria Carmen Diaz,Sousa Catarina,Souster Emily,Sparkes Andrew,Spencer-Chapman Michael,Squares Janet,Stanley Robert,Steed Claire,Stickland Tim,Still Ian,Stratton Mike,Strickland Michelle,Swann Allen,Swiatkowska Agnieszka,Sycamore Neil,Swift Emma,Symons Edward,Szluha Suzanne,Taluy Emma,Tao Nunu,Taylor Katy,Taylor Sam,Thompson Stacey,Thompson Mark,Thomson Mark,Thomson Nicholas,Thurston Scott,Toombs Dee,Topping Benjamin,Tovar-Corona Jaime,Ungureanu Daniel,Uphill James,Urbanova Jana,Van Philip Jansen,Vancollie Valerie,Voak Paul,Walker Danielle,Walker Matthew,Waller Matt,Ward Gary,Weatherhogg Charlie,Webb Niki,Wells Alan,Wells Eloise,Westwood Luke,Whipp Theo,Whiteley Thomas,Whitton Georgia,Widaa Sara,Williams Mia,Wilson Mark,Wright Sean

Funder

Wellcome Trust

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference78 articles.

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