Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis

Author:

Pinzaru Alexandra M.,Hom Robert A.,Beal Angela,Phillips Aaron F.,Ni Eric,Cardozo Timothy,Nair Nidhi,Choi Jaehyuk,Wuttke Deborah S.,Sfeir Agnel,Denchi Eros Lazzerini

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference67 articles.

1. Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis;Akbay;Oncogene,2013

2. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice;Artandi;Nature,2000

3. Germline mutations in shelterin complex genes are associated with familial glioma;Bainbridge;J. Natl. Cancer Inst.,2014

4. Pot1, the putative telomere end-binding protein in fission yeast and humans;Baumann;Science,2001

5. ATR disruption leads to chromosomal fragmentation and early embryonic lethality;Brown;Genes Dev.,2000

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